Evaluation of the immunochromatographic strip test for the rapid diagnosis of antenatal syphilis in women in Eldoret, Kenya.

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dc.contributor.authorNyamwamu, Lydia B.
dc.contributor.authorGicheru, Michael M.
dc.contributor.authorSharma, Rekha R.
dc.contributor.authorKimutai, Albert
dc.contributor.authorTonui, Willy K.
dc.contributor.authorKamau, Ngure Peter
dc.date.accessioned2024-11-19T11:57:30Z
dc.date.available2024-11-19T11:57:30Z
dc.date.issued2009
dc.descriptionJournal Article
dc.description.abstractObjective; This study compared the performance of the immunochromatographic strip (ICS) to the Venereal Disease Research Laboratory (VDRL) test and Treponema pallidum hemagglutination assay (TPHA) at a primary health care setting. Methods; The study group was comprised of 150 females randomly drawn from a population of pregnant women attending their first antenatal visit or follow-up visits at West Maternity Hospital in Eldoret Kenya, but without a previous syphilis test during that pregnancy. On-site VDRL, ICS and TPHA tests were performed and immediate treatment provided where appropriate. The performance of the three tests was compared. Results; The zero-prevalence of syphilis as determined by the VDRL test was 3%. There was no significant difference between the ICS and the VDRL test (P > 0.05). The sensitivity and specificity of the ICS test were 80% and 98.6% respectively, while the negative predictive value (NPV) and positive predictive value (PPV) were both 100%. On the other hand, the sensitivity and specificity of the VDRL test were 66.7% and 99.3%, while the NPV and PPV were 80% and 98.6% respectively. The Treponema pallidum hemagglutination assay was used as a reference test and had sensitivity, specificity, NPV and PPV of 100%.
dc.identifier.citationNyamwamu, L. B., Gicheru, M. M., Sharma, R. R., Kimutai, A., Tonui, W. K., & Ngure, P. K. (2009). Evaluation of the immunochromatographic strip test for the rapid diagnosis of antenatal syphilis in women in Eldoret, Kenya. Journal of Nanjing Medical University.
dc.identifier.urihttps://repository.daystar.ac.ke/handle/123456789/5651
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofseries(23)5
dc.subjectsero-prevalence of syphilis
dc.subjectnegative predictive value (NPV)
dc.subjectimmunochromatographic strip (ICS)
dc.titleEvaluation of the immunochromatographic strip test for the rapid diagnosis of antenatal syphilis in women in Eldoret, Kenya.
dc.typeArticle

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